The basic factor that creates difficulties in risk assessment in the modern processing industry relates to the increasing complexity of the chemical processing industry (CPI) plant due to technologically more complex and more demanding production processes. Continuous technological and overall social development on the world level is accompanied by growing quantitative and qualitative requirements for energy, food, various articles and chemical products. Fulfillment of these requirements implies the expansion of processing capacities and introduction of new technologies in the CPI plants. Risk assessment is a systematic process for assessing the impact, occurrence and outcome of human activities involving products or systems with hazardous characteristics. Hybrid methods of risk assessment are characterized by greater complexity in relation to qualitative and quantitative methods are characterized by a concept that is functional and sustainable only for particular purpose.